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When the cells are exposed to oxidative stress, NRF-2 escapes the negative regulation of KEAP1 through the increase of NRF-2, the transcription of interleukins decreases the levels of antioxidant response elements increase

In vitro experiments and in vivo studies employing animal models have demonstrated that SCFA supplementation elevates the transcriptional expression of TRPV6 and calbindin-D9k in both human colonic epithelial (Caco-2) cells and the colonic mucosa of rats (108, 185)

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206,207 Unlike diseases caused by alterations in genetic material, epigenetically mediated diseases are often induced by environmental factors